Name: | Amphotericin B | CAS: | 1397-89-3 |
---|---|---|---|
EINECS: | 215-742-2 | Related Name: | Amphotericin B Powder |
Other Name: | Pure Amphotericin B | COA: | Available |
Delivery: | In 3 Days | ||
High Light: | 1397-89-3 Amphotericin B Powder,Fungal Infections Amphotericin B Powder,1397-89-3 liposomal amphotericin b |
Highest quality 1397-89-3 Amphotericin B in stock fast delivery
Amphotericin B, also known as Lushanmycin, is a polyene antifungal antibiotic isolated from the culture broth of Streptomyces nodosus. It is produced by the actinomycetes isolated from the soil of Lushan in Jiangxi in 1974. Lushanmycin is the same substance, and it has significant effects on Cryptococcus neoformans, Saccharomyces dermatitis, Saccharomyces brasiliensis, Histoplasma capsulatum, S. schenckii, Candida albicans and several Nocardia, etc. Antibacterial effect. MIC is generally 0.2~0.5μg/ml. The molecular composition of Amphotericin B is a macrolide containing 7 pairs of conjugated double bonds as a ligand and a trehalose amine (mycosamine) deoxyhexose as a glycosyl group, which is connected by glycosidic bonds. There is an amino group and a carboxyl group in the structure, so it is an amphoteric substance. The appearance is yellow or orange-yellow powder, odorless or almost odorless, tasteless, with hygroscopicity, and it is easy to be damaged in sunlight. It decomposes gradually above 170ºC, and is unstable at 37ºC; It is soluble in dimethyl sulfoxide, slightly soluble in dimethylformamide, very slightly soluble in methanol, and insoluble in water, absolute ethanol, chloroform or ether. Salt can be formed in neutral or acidic medium, its water solubility increases but antibacterial activity will decrease. Its deoxycholate complex is a light yellow powder, which can form a colloidal solution in water and can be used for injection. This product can maintain stable performance for a long time under dry Chemicalbook, dark and cold storage conditions, but its aqueous solution should not exceed 24 hours at room temperature, and it can only be stored for one week at 4°C. The antibacterial effect is strongest at pH 6.0-7.5, and weaker at low pH. Its antibacterial mechanism is to combine with ergosterol on the fungal cell membrane, resulting in damage to the cell membrane, increased permeability, and death of intracellular substances escaped. Bacteria are ineffective because they do not contain ergosterol in their cell membranes. This product is not easily absorbed by oral administration, and the effective blood concentration can be maintained for more than 24 hours after intravenous drip. Not easy to penetrate the blood-brain barrier. Amphotericin B is effective against almost most fungi, drug-resistant strains are rare, and the price is low. This makes it possible to show high practical value in clinical applications for more than 40 years, but due to its obvious nephrotoxicity and infusion Related toxicity (such as fever, chills, nausea, etc.), the promotion and application of amphotericin B has been greatly restricted. In order to reduce adverse reactions, three liposome formulations of amphotericin B have been developed abroad in recent years: amphotericin B liposome, amphotericin B liposome complex (ABLC) and amphotericin B colloidal dispersion ( ABCD). Research data show that these three dosage forms of drugs not only ensure antifungal activity, but also significantly reduce the toxicity of amphotericin B, in particular, significantly reduce the incidence of nephrotoxicity, which not only improves patient tolerance, but also ensures The efficacy of the drug.
Amphotericin B Function
Amphotericin B is the drug of choice for deep fungal infections and has a broad antifungal spectrum. It has inhibitory effect on Cryptococcus, Coccidioides, Candida albicans, Blastomyces, etc., and has a bactericidal effect at high concentrations. It is an effective drug for the treatment of deep fungal infections. The main clinical indications are as follows: 1.Treatment of cryptococcosis, North American blastomycosis, disseminated candidiasis, coccidioidomycosis, and histoplasmic Chemicalbook mycosis. 2. Treatment of mucormycosis caused by Rhizopus, Absidia, Endosporium and Rana spp. 3.Treatment of sporotrichosis caused by Sporothrix schenckii. 4.Treat aspergillosis caused by Aspergillus fumigatus. 5.External preparations are suitable for pigment mycosis, skin fungal infections after burns, respiratory tract Candida, Aspergillus or cryptococcal infections, and fungal corneal ulcers.
Amphotericin B COA
PRODUCT NAME | Amphotericin B | ||||
CAS no. | 1397-89-3 | Outer packing | 1kg/Bag | ||
Production date | Mar.15,2021 | Shelf life | Mar.14,2023 | ||
Storage | Sealed and kept in a dry place | ||||
Items of analysis | Specification | Results | |||
Apperance |
Yellow to organe powder |
Complies | |||
Identification A:(UV) | Conforms to standard;absorbance in the range of 240nm to 320nm | Complies | |||
Identification A:(UV/Vis) | Conforms to standard;absorbance in the range of 320nm to 400nm | Complies | |||
Loss on drying | Not more than 5.0% | 0.8% | |||
Residue on Ignition | Not more than 3.0% | 0.5% | |||
Limit of amphotericn A | Not more tlian 15% | 3.9% | |||
Assay (microbial) | Not less than 750 μg/mg calculated on the dried basis | 832 μg/mg | |||
Microbial Limits | |||||
Total Aerobic Count | Not more than 100 CFU/gram | 0 CFU/gram | |||
Salmonella Species | Negative | Conforms | |||
Escherichia Coli | Negative | Conforms | |||
Residual Solvents | |||||
Ethanol | Not more than 5000 ppm | 434ppm | |||
Acetone | Not more than 5000 ppm | 1734ppm | |||
Conclusion | Conforms with enterprise standards |
Highest quality nr supplement powder CAS No.1341-23-7 buy online
23111 00 4 API Nicotinamide Riboside Chloride NR-CL Supplement Powder
Healthcare NMN Powder Medical Nad+ Nicotinamide Adenine Dinucleotide Treat Heart Disease
Anti Aging Nad Supplement Medicine Industry Powder Nicotinamide Adenine Dinucleotide