What was the NMN behind the hot "concept of immortality"?

July 23, 2020

一、What is NMN?

NMN(β-Nicotinamide Mononucleotide),it's precursor to NAD+ for the cofactor of the longevity protein in the human body, so before we get to know NMN, let's get to know NAD+ first.

NAD + also named coenzyme Ⅰ, full name is beta-Diphosphopyridine nucleotide, also known as nucleoside diphosphate, exist in each cell to participate in thousands reactions.

NAD+ is an important coenzyme in the tricarboxylic acid cycle, which promotes the metabolism of sugars, fats and amino acids and participates in the synthesis of energy.NAD+ is also the only substrate of coenzyme I depletion enzyme (the only substrate of DNA repair enzyme PARP, the only substrate of longevity protein Sirtuins, and the only substrate of cyclic ADP ribose synthetase CD38/157).

NAD+ is involved in all aspects of the human body's metabolism, is the key coenzyme.Lack of NAD+, metabolism is not, the elderly lack of NAD+, a variety of large and small problems will come, so through replenish additional NAD+ that can be a comprehensive anti-aging.

So, NAD+ is very important to the human body and plays an important role in the anti-aging of the human body. However, with the increase of age, the level of NAD+ in human body gradually decreases, so leading to the decrease of mitochondrial activity, accelerating the aging of mitochondria, cells and the whole body, and gradually entering a vicious cycle, which may be the reason for our aging.

From the perspective of NAD+ supplementation, the four precursors that can supplement the three metabolic cycles of NAD+ are niacin, tryptophan, niacinamide and NMN/NR. Compared with other supplementation methods of NAD+, NMN bypasses the bottleneck of NAMPT rate-limiting enzyme and can rapidly replenish NAD+ in body, which is the best ideal supplementation method. NAD+ molecules are relatively large, so it is difficult for NAD+ molecules directly supplemented from the outside to cross the cell membrane and enter the cell, but NMN molecules can easily cross the cell membrane and enter the cell. Once inside the cell, the two NMN molecules bind together to form an NAD+ molecule. Therefore, regular intake of this substance can effectively increase its content in the body, thus helping humans to repair DNA damage and delay aging!

二、Is NMN safe and reliable for long-term use?

NMN itself is a naturally occurring substance in the human body and is found in many foods, such as edamame and broccoli, which are naturally harmless. Studies have confirmed that supplementation of NMN does not affect the activity of various enzymes in the synthetic pathway of supplementation, and oral ADMINISTRATION of NMN does not affect the activity of NAMPT, PARP, NMNAT and other enzymes in the synthetic pathway of supplementation,it’s directly changes the level of NAD+ in body.

Why can't NMN be supplemented through food? Studies have shown that about 70kg of elderly people over 65 years old should be supplemented with about 600mg of NMN every day, and about 300mg for young people around 45 years old. This is equivalent to eating 32kg of edamame beans or 54kg of broccoli every day, and fully absorbed, which is impossible to achieve, so it is important to supplement non-food sources of NMN.

By the end of 2018, the NMN produced in port of gene had been certified as safe by GRAS(FDA evaluates safety indicators for food additives), which means it can be used as a safe food, comparable to the national blue cap. This is also the world's first GRAS certified NMN product.

三、What kind of people is NMN suitable for?

1.For the elderly ,use to assist in the improvement of various senile diseases;

2.Middle-aged people, use to eliminate or alleviate sub-health problems, such as chronic fatigue, poor sleep, vision loss, etc.;

3.Stay up late people, use to speed up body recovery;

4.Examinees, improve the ability to work under pressure, keep a clear mind;

5.Patients with higher radiation dose, such as radiologists, nurses and air crew, can improve the repair ability of genes damaged by radiation.

6.For cancer patients, it can help them repair genes, improve immunity and speed up physical recovery after radiotherapy and chemotherapy.

7.Bodybuilders, speed up muscle growth;

8.Athletes, improve energy level and reaction speed;

9.In drinkers, the genes that improve the ability to detoxify, protect the liver, and repair the toxic damage of acetaldehyde;

10.Smokers, use to reduce smoking addiction;

11.For depressed people, it can be increased dopamine level , mood can be improved, blood supply to the brain can be increased, and brain recession caused by depression can be alleviated.

12.Middle-aged and elderly women, improve skin health, delay skin aging;

13.Other persons who may low coenzym.