The introduction of PQQ:Pyrrolidoquinoline-quinone

January 28, 2021

What is PQQ?

Pyrrolidoquinoline-quinone is a new quinone protein progroup, which can transfer electrons reversively. As a cofactor of REDOX enzyme in the life system, it is the third coenzyme after riboflavin and nicotinamide, and was identified as B vitamins in 2003.
PQQ can promote animal and plant growth, development, anti-oxidation, anti-aging and enhance immunity.
This product is produced by biological fermentation process and belongs to fine chemical products.

Function of PQQ

1. Extensive nutritional functions

2. Antioxidant function

The production and scavenging of various free radicals in the organism should be in dynamic balance, that is, the free radicals in the organism should always maintain a certain level. Too much or too little free radicals are bad for the body. When too much, it can promote aging and cause various diseases, including cancer and heart disease. Too little, can also affect health or even hinder normal metabolism or induce another type of disease. PQQ prevents oxidative damage through the following mechanisms.

3. Research evidence of PQQ and various diseases

(1) Protect the heart from oxidative damage

The protective effect of PQQ on the heart is related to its ability to scavenge free radicals. PQQ can remove reactive oxygen species (ROS) produced by hypoxia reperfusion, and significantly reduce the release of lactate dehydrogenase in the heart. Under the catalysis of flavin reductase, the catalytic product can also reduce the peroxide status of hemoglobin and eliminate the damage to myocardium caused by hypoxia reperfusion. Studies have shown that the use of PQQ to protect the hearts of ischemia-reperfusion mice significantly reduced the size of myocardial infarction, increased the rate of left ventricular pressure and left ventricular diastolic pressure, reduced ventricular fibrillation, and reduced the level of malondialdehyde in myocardial tissue. PQQ can also inhibit the production of ROS in rat cardiomyocytes induced by hydrogen peroxide and the decrease of mitochondrial membrane potential, thereby reducing oxidative stress, inhibiting the inactivation of mitochondrial function and protecting rat cardiomyocytes .

2) Prevention and treatment of liver injury

Experimental liver injury in rats caused by carbon tetrachloride (CCL), galactosamine, acetamide sulfide and other toxins can be prevented by intraperitoneal injection of a certain dose of PQQ and its derivatives.
PQQ can reduce the production of ROS induced by liver toxicity, significantly reduce the levels of glutamic pyruvic transaminese (GPT) and lactate dehydrogenase in serum, block liver cell necrosis, and have no effect on the routine biochemical indexes (such as blood glucose, hematuric nitrogen, etc.) of rats.

(3) promote nerve growth and protect the nervous system

Nerve growth factor (NGF) is one of the earliest and most thoroughly studied neurotrophic factors. It has the dual biological functions of neuronal nutrition and neuroprotection, and plays an important role in regulating the growth, development, differentiation, regeneration and specific expression of biological functions of central and peripheral neurons. Experiments showed that PQQ could stimulate L-M cells and Schwann cells to generate NGF in vitro.