November 20, 2019
Application of methylcobalamin
Methylcobalamin is an endogenous coenzyme B12. In general, methylcobalamin is a vitamin B12, which is a coenzyme type vitamin B12 that can be directly used by the human body and is present in blood and marrow fluid.
Compared with vitamin B12, it has a good effect on the conduction of neurons. It can promote nucleic acid-protein-lipid metabolism through methylation reaction. As a coenzyme of methionine synthase, it can make homocysteine. It is converted into methionine, which participates in the synthesis of thymidine by deoxynucleoside, promotes nucleic acid and protein synthesis, promotes intraaxial axonal transport and axonal regeneration, and forms myelis, prevents axonal degeneration, and repairs damaged nerve tissue.
Among all vitamin B12, methylcobalamin participates in the methyl transmission of human nervous tissue and repairs damaged nerves. Therefore, methylcobalamin is used as a therapeutic agent for peripheral neuropathy for treating and improving neuropathic pain and numbness. Of course, it can also be converted into adenosine cobalamin in the human body to participate in other life activities of the human body, so it can also be used for other vitamin B12 deficiency.
Diabetic peripheral neuropathy (DPN) is a peripheral neurological dysfunction caused by hyperglycemia. It is a common complication and can be complicated by retinal hemorrhage and neovascularization. It is the main cause of disability in diabetic patients.
DPN studies have shown that methylcobalamin can promote the metabolism of lipids, nucleic acids and proteins through methyloxidation, repair damaged nerves, accelerate the regeneration of axons, and promote the synthesis of injured myelin lecithin.
Usage and adverse reactions
The dosage of methylcobalamin tablets is 0.5 mg/time for adults and 3 times a day, depending on the age and symptoms. If it is not effective for more than one month, you do not need to continue taking it. Workers working on mercury and its compounds should not take it in large quantities for a long time.
The adverse effects of methylcobalamin are occasional rashes, headaches, fever, sweating, pain and induration at the intramuscular site. It can cause severe allergic reactions such as blood pressure drop and difficulty breathing.
Long-term use of methylcobalamin tablets can cause hypokalemia and hyperuricemia. If it is a nervous system damage, it should not be applied when it is not diagnosed. Patients should not be blindly overdose when taking this medicine. Be sure to follow the doctor's advice.
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