Chondroitin sulfate exists in all organisms from nematodes to humans except plants, and plays many important physiological functions. Although the main chain structure of the polysaccharide is not complicated, it exhibits a high degree of heterogeneity in terms of the degree of sulfation, the distribution of the sulfate group and the two isomeric uronic acid rechains. The fine structure of chondroitin sulfate determines the specificity of the function and interaction with a variety of protein molecules.
Chondroitin sulfate Function
1. The main application method in medicine is as a medicine for treating joint diseases. It is used together with glucosamine to have analgesic effect and promote cartilage regeneration, which can fundamentally improve joint problems.
Randomized placebo-controlled clinical trials have demonstrated that chondroitin sulfate can reduce pain in patients with osteoarthritis, improve joint function, reduce joint swelling and effusion to prevent gap narrowing in the knee joint and hand joint. Provide cushioning and ease action The impact and friction can inhale moisture into the proteoglycan molecules, thicken the cartilage, and increase the amount of synovial fluid in the joint. One of the important functions of chondroitin is as a delivery conduit that delivers important oxygen supplies and nutrients to the joints, helping to remove waste from the joints while eliminating carbon dioxide and waste. Since there is no blood supply to the articular cartilage, all oxygenation, nourishment and lubrication are derived from synovial fluid.
2, chondroitin sulfate has a protective effect on corneal collagen fibers, can promote the growth of fibers in the matrix, enhance permeability, improve blood circulation, accelerate metabolism, promote the absorption of permeate and eliminate inflammation; its polyanion has strong water retention Sexuality can improve the water metabolism of the cornea tissue, have a strong affinity for the cornea, and form a breathable water-repellent film on the surface of the cornea to improve the symptoms of dry eyes. By promoting the formation of matrix, providing a framework for cell migration, it is beneficial to the migration of corneal epithelial cells, thereby promoting the healing of corneal wounds, the absorption of exudate and the elimination of inflammation.
3, through high-tech deep processing, can treat neurological headache, trigeminal neuralgia, coronary heart disease, angina pectoris, myocardial hypoxia, cardiovascular and cerebrovascular diseases, joint pain, atherosclerosis and hepatitis, etc., CS also has anticoagulation and Antithrombotic effects can also be used for adjuvant treatment of hearing impairment and liver function damage caused by streptomycin and adjuvant treatment of hyperlipidemia.
4, can be used as health care products, food additives, with the body's physical and anti-bacteria, beauty, anti-aging and other effects. Improves hearing and dry skin. In the body can inhibit the absorption of lipids and glucose in the small intestine to achieve weight loss.
CS is widely found in human and animal cartilage tissues. The pharmaceutical preparation mainly contains two isomers of chondroitin sulfate A and chondroitin sulfate C, and the content of chondroitin sulfate in the cartilage of animals of different varieties and ages is different. Its pharmacological effects are as follows:
1, CS can remove lipids and lipoproteins in the blood, remove cholesterol from the blood vessels around the heart, prevent atherosclerosis, and increase the conversion rate of lipids and fatty acids in the cells.
2, CS can effectively prevent coronary heart disease. Anti-atherosclerosis and anti-atherogenic plaque formation in experimental arteriosclerosis models; increased coronary atherosclerosis or collateral circulation in atherosclerosis, and can accelerate the occurrence of experimental coronary arteriosclerosis or embolism Healing, regeneration and repair of myocardial necrosis or degeneration.
3. It can increase the biosynthesis of the cell's messenger ribonucleic acid (mRNA) and deoxyribonucleic acid (DNA) and has the effect of promoting cell metabolism.
4, low anticoagulant activity. Chondroitin sulfate has a mild anticoagulant effect, and each 1 mg of chondroitin sulfate A corresponds to the anticoagulant activity of 0.45 U heparin. This anticoagulant activity does not depend on antithrombin III, which exerts anticoagulant activity through the fibrinogen system.
5, chondroitin sulfate also has anti-inflammatory, accelerate wound healing and anti-tumor effects.chondroitin 4 sulfate,chondroitin 6 sulfate for hourses.
Chondroitin sulfate Application
Long-term clinical applications have found that lipids such as fat deposited on arterial and venous walls can be effectively removed or reduced, significantly reducing plasma cholesterol, thereby preventing the formation of atherosclerosis.
Chondroitin sulfate is used to treat neuralgia, neuropathic migraine, joint pain, arthritis, and scapular joint pain, pain after abdominal surgery.
Prevention and treatment of hearing impairment caused by streptomycin and hearing difficulties caused by various noises, tinnitus, etc., have significant effects.
It has an auxiliary therapeutic effect on chronic nephritis, chronic hepatitis, keratitis and corneal ulcer.
Chondroitin in shark cartilage has an anti-tumor effect. In addition, chondroitin sulfate is also applied to cosmetics and healing agents for traumatic wounds and the like. Chondroitin sulfate is an acidic mucopolysaccharide, which is one of the important components in ocular tissues. It promotes corneal water metabolism and improvement, and is suitable for visual fatigue and dry eye syndrome.
Chondroitin sulfate Specification