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White Rapamycin Pharmaceutical Raw Material Macrolide Compound Promote Tumor Growth

Basic Information
Place of Origin: China
Brand Name: rapamycin cost
Certification: ISO
Model Number: rapamycin
Minimum Order Quantity: 10 grams
Price: Inquiry
Packaging Details: 1kg/bag;25kg/Durm
Delivery Time: 1-3work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000kg per Month
Detail Information
Name: Topical Rapamycin CAS: 53123-88-9
EINECS: 610-965-5 Flashing Point: 87 °C
Storage Condition: -20°C Solubility: Ethanol: Soluble2MM
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Product Description

Buy best rapamycin powder Cas 53123-88-9 with lowest cost

 

Rapamycin Description
Rapamycin is a macrolide compound obtained from streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production.

Rapamycin Function

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.

Rapamycin Application

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties.

Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.

Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth.

Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.

Rapamycin Specification
PRODUCT NAME Rapamycin
Batch number ACT20191228 Quantity 7.6kg
Storage Sealed to keep away from moisture
Items of analysis Specification Results
Appearance White powder Conforms
Identification Meet the requirements Conforms
PH 2.4~3.0 2.60
Loss on drying ≤0.5% 0.04%
Sulphated ash ≤0.1% 0.01%
Heavy metals ≤20 ppm <20 ppm
Related substances ≤0.25% Conforms
Residue on ignition ≤0.1% 0.01%
Residue solvent - Ethanol ≤0.5% <0.06%
Assay 99.0%~101.0% 99.6%

 

Conclusion

 

Conform with enterprise standard

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