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Professional Pharmaceutical Raw Material Uric Acid Medication Allopurinol Powder 315 30 0

Basic Information
Place of Origin: China
Brand Name: Sigma
Certification: ISO
Model Number: allopurinol price
Minimum Order Quantity: 25kg
Price: USD68-85per kg
Packaging Details: 1kg/bag,25kg/drum
Delivery Time: 3 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per month
Detail Information
Name: Allopurinol Price Cas No.: 315-30-0
EINECS NO.: 206-250-9 MW: 136.11
Test Method: HPLC Usage: Animal Pharmaceuticals
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Product Description

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Allopurinol Introduction

Allopurinol (allopurinol) is structured around Xanthine compounds (seventh in the purine ring is c, eighth, n), the inhibition of Xanthine oxidase has a strong, often used to treat gout.
This product is white or almost white crystalline powder almost odourless. This product is very slightly dissolve in water or ethanol, insoluble in chloroform or ether; in a solution of sodium hydroxide or potassium hydroxide soluble.

Allopurinol Function

 

1. Thiopurine co-therapy

 

Allopurinol CAS 315-30-0 can cause severe pancytopenia if given with full-dose mercaptopurine or its pro-drug azathioprine, due to the inhibition of xanthine oxidase that metabolizes mercaptopurine. For this reason, allopurinol CAS 315-30-0 has been strongly contraindicated during thiopurine therapy in the past. However, in recent years the use of allopurinol cas 315-30-0 in combination with azathioprine or mercaptopurine has been revived. First, allopurinol cas 315-30-0 was shown that an azathioprine/allopurinol combination significantly improved renal transplant graft survival. More recently, allopurinol cas 315-30-0 was discovered that this co-therapy greatly improves the outcome for patients that do not respond to thiopurine monotherapy when treating inflammatory bowel disease (IBD), specifically Crohn's disease.

 

2. Reperfusion injury

 

Other established indications for allopurinol therapy include ischemic reperfusion injury, kidney stones with a uric acid component (uric acid nephrolithiasis), and protozoal infections (Leishmaniasis).

 

3. Renal disease, Heart failure and Angina

 

Allopurinol can be used in patients with poor kidney function, but it may also help them. A study of allopurinol use in patients with chronic kidney disease suggested that "Allopurinol decreases C-reactive protein and slows down the progression of renal disease in patients with chronic kidney disease. In addition, allopurinol reduces cardiovascular and hospitalization risk in these subjects."

 

4. Epilepsy

 

Allopurinol CAS 315-30-0 is used as an add-on drug for refractory epilepsy, because it is an adenosine agonist, which inhibits glutamine release from excitatory neurons, but does not change the plasma concentration of other epilepsy drugs.

 

5. Blood pressure

 

Allopurinol CAS 315-30-0 can decrease blood pressure reducing hypertension.

 

Allopurinol Specification

PRODUCT NAME Allopurinol
CAS no. 315-30-0 Outer packing 1KG/foil bag
Storage Store in a well-closed container away from moisture
Items of analysis Specification Results
Description White or almost white powder White powder
Solubility Very slightly soluble in water and alcohol practically insoluble in ether.it dissolves in dilute solutions of the alkali hydroxide. Complies
Identification Infrared absorption(197K),The IR absorption spectrum of sample exhibits the same spectrum as Reference Standard Complies
Loss on drying ≤0.5% 0.12%
Related substances by HPLC Impurity A≤0.2% 0.03%
  Impurity B≤0.2% Not detected
  Impurity C≤0.2% Not detected
  Impurity D≤0.2% 0.03%
  Impurity E≤0.2% 0.02%
  Impurity F≤0.2% Not detected
  Any individual unspecified impurity≤0.1% 0.02%
  Total impurity≤1.0% 0.30%
Limit of hydrazine ≤10ppm Complies
Assay 98.0%~101.0% 99.96%
Conclusion Conforms to USP38 standard

 

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