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Pharmaceutical grade Allopurinol API blood pressure for tumor lysis cas 315-30-0
Product Name Allopurinol
Chemical Name 4-hydroxypyrazolo[3,4-d] pyrimidine
CAS Number 315-30-0
Molecular Formula C5H4N4O
Molecular Weight 136.1
Allopurinol used primarily in gout attack phase and the chronic phase, applied to generate too much uric acid, uricosuric allergy or is invalid, as well as urination drugs should not be used (such as renal insufficiency) of primary and secondary gout, hyperuricemia control. The drug can also be combined with uricosuric to enhance efficacy, especially in serious tophi and kidney patients is good.
1. Gout and hyperuricemia
Subsequently the uric acid lowering capacity of allopurinol was noted and the drug went on to be developed for its more famous use: to treat hyperuricemia (excess uric acid in blood plasma) and its complications. Allopurinol CAS 315-30-0does not alleviate acute attacks of gout, and there is currently controversy over the issue of whether it can actually make acute gout attacks worse initially, but is useful in chronic gout to prevent future attacks.
2. Tumor lysis syndrome
Allopurinol CAS 315-30-0 was also commonly used to treat tumor lysis syndrome in chemotherapeutic treatments as these regimes can rapidly produce severe acute hyperuricemia, although it has gradually been replaced by urate oxidase therapy.
1.Allopurinol reduces the production of uric acid in your body. Uric acid buildup can lead to gout or kidney stones.
2. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.
|CAS no.||315-30-0||Outer packing||1KG/foil bag|
|Storage||Store in a well-closed container away from moisture|
|Items of analysis||Specification||Results|
|Description||White or almost white powder||White powder|
|Solubility||Very slightly soluble in water and alcohol practically insoluble in ether.it dissolves in dilute solutions of the alkali hydroxide.||Complies|
|Identification||Infrared absorption(197K),The IR absorption spectrum of sample exhibits the same spectrum as Reference Standard||Complies|
|Loss on drying||≤0.5%||0.12%|
|Related substances by HPLC||Impurity A≤0.2%||0.03%|
|Impurity B≤0.2%||Not detected|
|Impurity C≤0.2%||Not detected|
|Impurity F≤0.2%||Not detected|
|Any individual unspecified impurity≤0.1%||0.02%|
|Limit of hydrazine||≤10ppm||Complies|
|Conclusion||Conforms to USP38 standard|