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Long Acting Weight Losing Raw Material CAS 96829 58 2 Orlistat And Weight Loss

Basic Information
Place of Origin: China
Brand Name: Sengmei
Certification: ISO
Model Number: Orlistat
Minimum Order Quantity: 1kg
Price: USD 720~780/kg
Packaging Details: 1kg/bag;25kg/Durm
Delivery Time: 1-3work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000kg per Month
Detail Information
Name: Orlistat CAS: 96829-58-2
EINECS: 639-755-1 Purity: 99%
Color: White Form: Powder
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Product Description

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Orlistat Description

Orlistat is internationally recognized as a new type of lipid-lowering medicine reducing weight, sales of the commodity name on the market for saini, listed in New Zealand for the first time in 1998, the sales of $146 million, sold $538 million in 2007, currently orlistat global weight loss market 80% market share, China only Hong Kong reached $80 million a year in sales.
Orlistat is a long-acting and potent specific gastrointestinal lipase inhibitor, white or white powder at room temperature, insoluble in water, soluble in chloroform, soluble in ethanol, and deactivated by covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the stomach and small intestinal lumen.The fat in food cannot be decomposed into free fatty acids and monoacylglycerol, so the fat cannot be absorbed and utilized, thus reducing the calorie intake of the body and controlling the weight.The drug works without systemic absorption.
The absorption of fat can be inhibited by up to 30% at commonly used doses.After oral administration, it is rarely absorbed, and can be metabolized and inactivated in the intestinal tract. The metabolic site is in the wall of the gastrointestinal tract, and the elimination half-life is about 14~19 hours.About 97% of the product is excreted with feces, of which 83% is excreted in its original form.Orlistat can be used in obesity and hyperlipidemia.In general, 120mg can be taken orally three times a day during or 1 hour after meals.Weight loss can begin after 2 weeks of medication.Can be taken continuously for 6 to 12 months, if the dosage increases to more than 400mg daily, the effect no longer increases.

Orlistat Function

Orlistat is used with a low-calorie diet to help you lose weight and to maintain your weight after weight loss.
Orlistat is in a class of drugs called lipase inhibitors. It works in your intestines, where it blocks some of the fat you eat from being absorbed and digested. This undigested fat is then removed in your bowel movements .

Orlistat Application

Orlistat is used for the treatment of obesity.The amount of weight loss achieved with orlistat varies. In one-year clinical trials, between 35.5% and 54.8% of subjects achieved a 5% or greater decrease in body mass, although not all of this mass was necessarily fat. Between 16.4% and 24.8% achieved at least a 10% decrease in body mass.After orlistat was stopped, a significant number of subjects regained weight—up to 35% of the weight they had lost.

The incidence of type 2 diabetes in an obese population over four years is decreased with orlistat (6.2%) compared to placebo (9.0%).Long-term use of orlistat also leads to a modest reduction in blood pressure (mean reductions of 2.5 and 1.9 mmHg in systolic and diastolic blood pressure respectively).

Orlistat Specification
PRODUCT NAME Orlistat
CAS no. 96829-58-2 Quantity 50kg
Storage In an airtight container, protected from light.
Items of analysis Specification Results
Appearance while to off-while powder White powder
Identification HPLC retention time Conforms
Melting Point 42 ºC -45°C 42°C-44°C
Specific optical rotation -31.0°~-41.0° -36.0°
Purity by HPLC no less than 99.0% 99.8%
Total impurity no more than 2.0% 1.6%
Max Individual impurity no more than 0.5% 0.32%
Water content%(K&F) no more than 0.5% 0.1%
Residual solvents EtOH no more than 0.5% N.D
  EtAC no more than 0.5% N.D
  n-Heptane no more than 0.5% less than 0.12%
Residue on ignition less than 0.2% 0.10%
Assay (HPLC) no less than 99.0% 99.60%
Conclusion Conforms with Specification

 

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