CAS 4759-48-2 Raw Material Vitamin A Analogues For Oral Isotretinoin Capsules

Basic Information
Place of Origin: China
Brand Name: isotretinoin gel
Certification: ISO
Model Number: oral isotretinoin
Minimum Order Quantity: 1kg
Price: Inquiry
Packaging Details: 1kg/bag,25kg/drum
Delivery Time: 3 work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 500kg per month
Detail Information
Name: Isotretinoin Capsules CAS No.: 4759-48-2
EINECS No.: 225-296-0 Assay: HPLC99%
Form: Yellow Powder Type: Vitamins, Amino Acids And Coenzymes
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Product Description

CAS 4759-48-2 raw material use for oral isotretinoin capsules and gel


Isotretinoin Introduction

Isotretinoin (13-cis-Retinoic acid )is a vitamin A analog that inhibits cell proliferation and induces cell differentiation. Clinically,13-cis-Retinoic acid is primarily used in the treatment of severe recalcitrant nodular acne.
Its effects include reducing the production of sebum,shrinking the size of the sebaceous glands, stabilizing keratinization,preventing comedones from forming, and reducing inflammation of inflammatory acne.
Though the exact mechanism of action of 13-cis-Retinoic acid is not fully understood, studies have suggested that the compound alters DNA transcription and induces apoptosis in select types of cells throughout the body.

Isotretinoin Function

1. Isotretinoin is a drug commonly used to treat acne vulgaris and keratosis pilaris.
2. Isotretinoin is available as a cream or gel. It is also used to treat acute promyelocytic leukemia.
3. Isotretinoin is also used off-label to treat and reduce the appearance of stretch marks by increasing
collagen production in the dermis.
4. In topical form, this drug is pregnancy category C and should not be used by pregnant women.
5. People using the topical form should not also use any cream or lotion that has a strong drying effect,
contains alcohol,astringents,spices,lime,sulfur,resorcinol,or aspirin,as these may interact with
tretinoin or exacerbate its side effects.
6. Isotretinoin can stimulate skin growth and keep epidermic normal.
7. Isotretinoin can slow down skin aging process for solarization,remove tiny wrinkles.

Isotretinoin Specification
Product name Isotretinoin CAS:4759-48-2
Items Standard result
Appearance Yellow crystalline powder Yellow crystalline powder
Loss on Drying ≤ 0.2% 0.03%
PH 5.0-8.0 6.8-7.2
Heavy Metal ≤ 1ppm 0.0006ppm
As ≤ 0.5ppm 0.0002ppm
Yeasts & Molds <100 cfu/g comfirm
E.coli Negative(10g) comfirm
Salmonella Negative(25g) comfirm
Total Plate count <1000cfu/g 500cfu/g
Content ≥325,000 IU/G comfirm
Assay 98%-102% 99.68%

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