Quinine is one of the oldest antimalarial drugs. The cinchona bark containing quinine has been widely used as a potent drug for the treatment of malaria as early as the 15th century. Its antimalarial effect is similar to that of chloroquine. effect. Can inhibit the red blood cell phase of various malaria parasites and control the onset of malaria symptoms. It also has a certain killing effect on the gametophyte of P. vivax and P. vivax. However, it has no effect on the extracellular period of red blood cells. Its main advantage is that it is not easy to produce drug resistance. It may be that the DNA binding mode of quinine and Plasmodium is different from that of chloroquine, so there is no cross-resistance. In addition, quinine has the effect of exciting the uterus, inhibiting the heart muscle and antipyretic and analgesic. In addition to medicine, it can be used as a detection agent for metal ions such as bismuth and platinum in analytical chemistry, and it can also be used as a separating agent for racemic organic acids. This product is quickly and completely absorbed orally, and the blood concentration can reach a peak within 1 to 3 hours. The binding rate to plasma proteins is about 70%. The concentration in cerebrospinal fluid is about 2% to 5% in plasma. The half-life Chemicalbook is 7-8 hours. Can be absorbed quickly through the placenta, subcutaneously and intramuscularly. Mainly metabolized by the liver, 5% of the dose is excreted from the urine in its original form. Clinically, quinine is mainly used in patients with Plasmodium infection that are resistant to chloroquine. It is also used for vivax and falciparum. Quinine salts are used in medical facilities. Sulfate is for oral administration and hydrochloride is for injection. Until the 1920s, it was a better medicine for malaria. However, if used improperly, it can also cause poisoning, causing headache, tinnitus, diarrhea, rash, vision and hearing disorders. It only has an inhibitory effect on the original malaria, but has no killing effect, and the patient is still prone to attack after healing. To this end, scientists are still looking for more effective antimalarial drugs. Alpin, quinaloline and chloroquinoline have been used. A plant known as Changshan can be extracted from Chinese plant Changshan. Its antimalarial effect is more than 100 times greater than that of quinine, but it cannot be taken directly because of its high toxicity. The structure and pharmacological relationship of Changshan is being studied to find out more effective High antimalarial.