ciprofloxacin urinary tract infection,
ampicillin sensitive enterococcus
API pure Florfenicol powder for poultry CAS 73231-34-2 in lowest price bulk
Florfenicol is a commonly used veterinary antibiotic. It has a broad spectrum of antibacterial activity, strong antibacterial activity, low minimum inhibitory concentration (MIC), and antibacterial effect is 15-20 times that of chloramphenicol and thiamphenicol. 60 minutes after administration, the concentration of the drug in the tissue can reach a peak, which can quickly control the disease, with high safety, no toxicity, no residue, etc., and no hidden dangers of aplastic anemia, suitable for large-scale large-scale farm use, mainly It is used to treat bovine respiratory diseases caused by Pasteurella and Haemophilus. It has a good effect on bovine rot disease caused by Fusobacterium. It is also used for bacterial diseases of pigs, chicken infectious diseases and fish caused by sensitive bacteria.
Florfenicol is not easy to produce drug resistance: because the fluorine atom replaces the hydroxyl group in the molecular structure of thiamphenicol, the problem of resistance to chloramphenicol and thiamphenicol is effectively solved. Strains that are resistant to Thiamphenicol, Chloramphenicol, Amoxicillin, and Quinolone are still sensitive to this product. Because chloramphenicol has serious adverse reactions such as aplastic anemia and immunosuppression, it is prohibited in food animal production. Studies have shown that the main group causing aplastic anemia in the chemical structure of chloramphenicol is the para-nitro group on the aromatic ring. The florfenicol replaces the NO2 group with CH3SO4, which changes the chemical structure, so it is used in animals without the adverse reactions of aplastic anemia. As a result, more than a dozen countries in Japan, Mexico and China have been approved for use. The characteristics of florfenicol are: broad spectrum of antibacterial, against Salmonella, Escherichia coli, Proteus, Haemophilus, Actinobacillus pleuropneumoniae, Mycoplasma hyopneumoniae, Streptococcus suis, Pasteurella multocida, B. bronchiseptica , Staphylococcus aureus, etc. are sensitive.
The drug is easy to absorb and widely distributed in the body, and is a quick-acting, long-acting preparation with no potential for aplastic anemia, and has good safety. In addition, the price is moderate, and it is cheaper than other drugs for preventing and treating respiratory diseases such as tiamulin (Tianyuanjing), tilmicosin, azithromycin, etc., and the cost of medication is easy for users to accept. Due to these characteristics, domestic florfenicol has been widely used, and it has become the drug of choice for the prevention and treatment of bacterial infections in the respiratory and digestive tract of livestock and poultry. Florfenicol should not be combined with quinolones, penicillins, and cephalosporins, and should not be compatible with ampicillin, sulfonamides, and furans.
1. To pig pleurisy, streptococcus, attach red filaments, day 2, diarrhea effects.
2. To chickens of contagion rhinitis, pig, ox lung phytophthora duck respiratory infection, inflammation, RuXianYan serous disease such as effects.
3. The aquatic product categories: for bacterial enteritis sepsis, disease, red skin disease, vibrio disease, perpendicular scale disease, class nodules disease, Enoch concurrent salmonellosis, scabies disease, eel red eosinophilic disease and bullfrogs bacterial dysentery effects.
Florfenicol was originally mainly used in aquaculture and was effective in the treatment of yellow-tailed fish with pseudonuclear pasteurellosis, streptococcal disease, and naturally occurring Atlantic salmonids. Oral administration has a good protective effect against Pasteurella multocida infection, delayed edward Edwardia infection, Vibrio anguillarum infection, and killing of Vibrio anguillarum infection, and the curative effect is superior to other commonly used antimicrobial agents (Qiu Yinsheng et al. , 1996). The efficacy of florfenicol in the treatment of bovine respiratory diseases is significant. Hass (1996) reported that florfenicol was administered intramuscularly at a dose of 20 mg kg-1.bw for bovine respiratory disease, with a cure rate (80%) significantly higher than that of amoxicillin treatment. Group (50%). Madelent et al. (1997) reported treatment of respiratory diseases with the same dose. The cure rate of florfenicol (91%) was also significantly higher than that of spiramycin (41%). Ueda (1995) treated human-induced pleuropneumoniae pleuropneumoniae with 50ppm mixed feed, the cure rate was 100%; and the cure rate of the thiamphenicol treatment group (200ppm) was less than 50%. Craene (1997) reported a single-dose intravenous injection of florfenicol (20 mg kg-1) that penetrated well into cerebrospinal fluid with a peak concentration (Cmax) of 4.67±1.51 ug ml-1 and an average retention time (MRT) of 8.7 hours. , Can maintain the effective plasma concentration of Haemophilus 20h, can be used as the drug of choice for the treatment of meningitis. Pharmacokinetic studies of florfenicol in lactating dairy cows (Soback, et al, 1995) showed that breast perfusion administration was superior to intramuscular injection, and plasma concentrations were significantly higher than plasma concentrations after 4 hours of intravenous infusion, and bioavailability ( 54%) is higher than the bioavailability (38%) of intramuscular injection, which has important practical significance for the treatment of mammary glands in bovine mammary glands. After oral administration of florfenicol (30 mg/kg.bw), broilers had a bioavailability of 55.3% with a plasma protein binding rate of 18.5%. After broiler chickens were injected with florfenicol (30 mg/kg.bw), the bioavailability was 96.6% (Afifi, 1997); Pasteurella multocide-injected florfenicol (30 mg/kg.bw) had a bioavailability of 73.%, higher than that of healthy ducks. [Usage and dosage of fish] Mixed feeding: The fish is fed with 10 to 15 mg of bait per 1kg body weight (in florfenicol), once a day, for 3 to 5 days.
|Storage||Store in a cool dry place,prevent strong sunlight.|
|Items of analysis||Specification||Results|
|Specific optical rotation||-16°~-19°||-17°|
|Loss on Drying||≤0.5 %||0.02%|
|Residue on ignition||≤0.1 %||0.02%|
|Conclusion||Conforms to Enterprise standards|