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Antimalarials Pharmaceutical Raw Material Pure Quinine Powder Cas 130-95-0

Basic Information
Place of Origin: China
Brand Name: quinine
Certification: ISO
Model Number: quinine powder
Minimum Order Quantity: 100 grams
Price: Inquiry
Packaging Details: 1kg/bag;25kg/Durm
Delivery Time: 1-3work days
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 5000kg per Month
Detail Information
Name: Quinine CAS: 130-95-0
EINECS: 205-003-2 MF: C20H24N2O2
MW: 324.42 Form: Powder
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Product Description

Top grade pure quinine powder Cas 130-95-0 buy online

 

Quinine Description
Quinine, also known as Cinchona and Cinchona, is the main alkaloid in the bark of the Rubiaceae plant Cinchona and its genus. Cinchona bark contains more than 20 alkaloids. Malaria also has quinidine, sinconine, and sinconidine. All alkaloids from cinchona bark are used as antimalarials and antipyretics, which are called cinchona all-alkali or quinine. Quinine is chemically quinoline and is an isomer of quinidine. White amorphous powder or crystal, odorless and extremely bitter. Melting point is 172.8 ° C, it has left optical rotation, [α] D20-168 ° (ethanol). Soluble in ethanol, chloroform, benzene and ether, slightly soluble in water. Its dilute sulfuric acid solution has blue fluorescence, and bromine and excess ammonia are added dropwise, and it is emerald green. Cinchona bark powder is treated with lime and sodium hydroxide, extracted with kerosene, neutralized with dilute sulfuric acid, and the precipitated quinine sulfate is reacted with ammonia to obtain it. Chemicalbook can also be synthesized from m-hydroxybenzaldehyde and α-aminoacetaldehyde. It is used to treat and prevent various malaria. Quinine sulfate: white fine needle-like crystals, soft, easy to compress, odorless, bitter taste, gradually brown to sunlight, its saturated aqueous solution shows left-handedness and neutral reaction, slightly soluble in water and ethanol . Quinine hydrochloride: colorless or white satin-like needle-like crystals, odorless, extremely bitter, gradual color change in sunlight, weatherable, soluble in water, easily soluble in boiling water, easily soluble in ethanol or Chloroform. Quinine dihydrochloride: white powder, odorless, bitter taste, gradual change in color under sunlight, aqueous solution shows acidic reaction, easily soluble in water, soluble in ethanol, slightly soluble in chloroform, insoluble in ether. Important derivatives of quinine, such as ethyl carbonate (euquinine), are also known as "odorless quinine" because they have no bitterness and are intended for oral use by children.

Quinine Function

Quinine is one of the oldest antimalarial drugs. The cinchona bark containing quinine has been widely used as a potent drug for the treatment of malaria as early as the 15th century. Its antimalarial effect is similar to that of chloroquine. effect. Can inhibit the red blood cell phase of various malaria parasites and control the onset of malaria symptoms. It also has a certain killing effect on the gametophyte of P. vivax and P. vivax. However, it has no effect on the extracellular period of red blood cells. Its main advantage is that it is not easy to produce drug resistance. It may be that the DNA binding mode of quinine and Plasmodium is different from that of chloroquine, so there is no cross-resistance. In addition, quinine has the effect of exciting the uterus, inhibiting the heart muscle and antipyretic and analgesic. In addition to medicine, it can be used as a detection agent for metal ions such as bismuth and platinum in analytical chemistry, and it can also be used as a separating agent for racemic organic acids. This product is quickly and completely absorbed orally, and the blood concentration can reach a peak within 1 to 3 hours. The binding rate to plasma proteins is about 70%. The concentration in cerebrospinal fluid is about 2% to 5% in plasma. The half-life Chemicalbook is 7-8 hours. Can be absorbed quickly through the placenta, subcutaneously and intramuscularly. Mainly metabolized by the liver, 5% of the dose is excreted from the urine in its original form. Clinically, quinine is mainly used in patients with Plasmodium infection that are resistant to chloroquine. It is also used for vivax and falciparum. Quinine salts are used in medical facilities. Sulfate is for oral administration and hydrochloride is for injection. Until the 1920s, it was a better medicine for malaria. However, if used improperly, it can also cause poisoning, causing headache, tinnitus, diarrhea, rash, vision and hearing disorders. It only has an inhibitory effect on the original malaria, but has no killing effect, and the patient is still prone to attack after healing. To this end, scientists are still looking for more effective antimalarial drugs. Alpin, quinaloline and chloroquinoline have been used. A plant known as Changshan can be extracted from Chinese plant Changshan. Its antimalarial effect is more than 100 times greater than that of quinine, but it cannot be taken directly because of its high toxicity. The structure and pharmacological relationship of Changshan is being studied to find out more effective High antimalarial.

Quinine Specification
PRODUCT NAME Quinine
Batch number ACT20191212 Quantity 25kg
Storage Sealed to keep away from moisture
Items of analysis Specification Results
APPERANCE White powder Conforms
SOLUBILITY insoluble Complies
SULPHATED ASH ≤0.1% 0.05%
THE RELATED IMPURITIES ≤ 1.5% 0.9%
LOSS ON DRYING ≤ 0.1% 0.05%
RESIDUE ON IGNITION ≤ 0.15% 0.05%
ASSAY 99.0%-101.0% 99.2%
Yeast and mold ≤100cfu/g <100
E.Coli Negative Absent
Salmonella Negative Absent
Staphylococcus Aureus Negative Absent
Conclusion Conform with enterprise standard

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